Indapamide is an oral antihypertensive/diuretic. Its molecule contains both a polar sulfamoyl chlorobenzamide moiety and a lipid-soluble methylindoline moiety. It differs chemically from the thiazides in that it does not possess the thiazide ring system and contains only one sulfonamide group.The chemical name of indapamide is 1-(4-chloro-3sulfamoylbenzamido)-2-methylindoline, and its molecular weight is 365.84. The compound is a weak acid, pKa=8.8, and is soluble in aqueous solutions of strong bases. It is a white to yellow-white crystalline (tetragonal) powder.
The tablets also contain microcrystalline cellulose, coloring agent, corn starch, pregelatinized starch, hypromellose, lactose, magnesium stearate, polyethylene glycol, and talc.
EINECS:248-012-7
Molecular Formula:C16H16ClN3O3S
CAS Registry Number:26807-65-8
Appearance:Crystalline Solid
Molecular Weight:365.83
Density:1.51 g/cm3
Melting Point:160-162oC
Refractive index:1.693
Solubility:Insoluble
Stability:Stable at normal temperatures and pressures.
Usage:Used as an antihypertensive. Diuretic
没有评论:
发表评论