1A,25-dihydroxycholecalciferol properties

1A,25-dihydroxycholecalciferol properties is an active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). Plays important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. It has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Known to act as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

1A,25-dihydroxycholecalciferol

Name:1A,25-dihydroxycholecalciferol

EINECS:250-963-8

Molecular Formula:C27H44O3

CAS Registry Number:32222-06-3

Synonyms:Vitamin D3, 1a,25-Dihydroxy-; 1alpha,25-Dihydroxyvitamin D3; 1a,25-
Dihydroxyvitamin; 1alpha,25-dihydroxycholecalciferol; (5z,7e)-(1s,3r)-9, 10-secocholesta-5,7,10(19)-triene-1,3,25-triol; 1α,25-dihydroxycholecalciferol; Calcitriol; 1,25-dihydroxyvitamin D3

InChI:InChI=1/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22+,23+,24?,25?,27+/m0/s1

Appearance:White Crystalline Powder

Molecular Weight:416.64

Density:1.06g/cm3

Boiling Point:565 °C at 760 mmHg

Melting Point:119-121°C

Flash Point:238.4 °C

Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO or EtOH. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Refractive index:1.547

Solubility:Insoluble

Biological Activity:Active metabolite of vitamin D 3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca 2+ absorption and regulates bone Ca 2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Usage:The biologically active form of vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic