Properties of clozapine

clozapine

Name:clozapine

EINECS:227-313-7

Molecular Formula:C18H19ClN4

CAS Registry Number:5786-21-0

InChI:InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3

Appearance:a yellow, crystalline powder, very slightly soluble in water

Molecular Weight:326.82326

Density:1.31 g/cm3

Boiling Point:477.8 °C at 760 mmHg

Melting Point:182-185°C

Flash Point:242.8 °C

Storage Temperature:Keep tightly closed.

Refractive index:1.681

Solubility:ethanol: 1 mg/mL in water

Biological Activity:Atypical antipsychotic drug, with a much lower tendency to cause extrapyramidal side effects than conventional neuroleptics.Displays a broad range of pharmacological actions; the antipsychotic effects are thought to be mediated principally by 5-HT 2A/2C and dopamine receptor blockade (K i values are 21, 170, 170, 230 and 330 nM for D 4 , D 3 , D 1 , D 2 and D 5 receptors respectively).

Stability:Stable at normal temperatures and pressures.

Usage:An antipsychotic

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