2–methylimidazole production

2-methylimidazole, also known as two-methylimidazole,it is white needle crystal or crystalline powder under room temperature . Relative molecular mass of 82.11. Melting point 145 ~ 146 °C. Boiling point 267 °C.it Can be sublimated. Flash point of 160 °C. Insoluble in ether, cold benzene, soluble in water, alcohols, ketones. Irritant to skin and mucous membranes. Mice by mouth LD501400mg/kg. 2 - methylimidazole pesticide production antitrichomonal Flagyl (metronidazole) intermediates. Is epoxy resin curing agent, and other curing accelerator, an amine curing agent occupies a special position in the epoxy resin curing agent in the temperature, may be used alone, in a short time after heat treatment, heating can be obtained cured high temperature deformation. It is mainly used for powder molding and powder coating curing accelerator. May 2 - imidazoline dehydrogenation.


1.Chemical properties
2-methylimidazole is Solid. Soluble in water, ethanol, slightly soluble in cold benzene.
2.Use
Metronidazole for pharmaceutical intermediates, epoxy resin curing agent,
The material is drug metronidazole and feed growth promoters dimethyl azole intermediates, as well epoxy and other resin curing agent. As the temperature of the solid epoxy resin through the agent may be used alone, but primarily for powder molding and powder coating curing accelerator.
2.Production
1)glyoxal, acetaldehyde, and ammonia as raw materials, the reaction of 2-methyl-imidazole crude, sublimation purification, can be obtained products.
2)ethylenediamine and acetonitrile as raw materials, the reaction in the presence of sulfur to produce imidazoline, again in the presence of a nickel catalyst, at 200 °C dehydrogenation, can be prepared from 2 - methylimidazole products.
3)to glyoxal and methylamine in the presence of formaldehyde reaction, can be obtained.

Production methods from 2-imidazoline dehydrogenation eliminated. 2-imidazoline heating and melting (melting point 107 °C), active nickel was added carefully, the reaction temperature was raised to 200-210 °C 2h. Cooling to below 150 °C, dissolved in water, hot pressure filtration, separation active nickel, the filtrate was concentrated to a temperature above 140 °C, discharge cooling that is to give 2-methylimidazole. With the production of a purity of ≥ 98% of the product, 1t products consume ethylene diamine (95%) 1095kg, acetonitrile 975kg. A better approach is to use glyoxal and formaldehyde as raw materials.