Chemical Properties of Fenofibrate

Fenofibrate (Abbott's Tricor) is a drug of the fibrate class. It is mainly used to reduce cholesterol levels in patients at risk of cardiovascular disease. Like other fibrates, it reduces both low-density lipoprotein (LDL) and very low density lipoprotein(VLDL) levels, as well as increasing high-density lipoprotein (HDL) levels and reducing triglycerides level. It is used alone or in conjunction with statins in the treatment of hypercholesterolemia and hypertriglyceridemia. Next is its chemical properties.


Name:Fenofibrate

EINECS:256-376-3

Molecular Formula:C20H21ClO4

CAS Registry Number:49562-28-9

InChI:InChI=1/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3

Appearance:White or yellowish crystalline powder

Molecular Weight:360.84

Density:1.177 g/cm3

Boiling Point:469.8 °C at 760 mmHg

Melting Point:80-81°C

Flash Point:165.4 °C

Storage Temperature:Keep tightly closed.

Solubility:0.1 mg/L (37 C)

Stability:Stable at normal temperatures and pressures.

Usage:Antilipemic. It is a lipid regulating drug. Increases high density lipoprotein levels by reducing cholesteryl ester transfer protein expresion.