Information about Apigenin

Apigenin, found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally occurring glycosides. It is a yellow crystalline solid that has been used to dye wool.

 Apigenin

Name:apigenin (Related Reference)

EINECS:208-292-3

Molecular Formula:C15H10O5

CAS Registry Number:520-36-5

Appearance:Pale Yellow Crystalline Solid

Molecular Weight:270.2369

Density:1.548 g/cm3

Boiling Point:555.5 °C at 760 mmHg

Melting Point:345-350℃

Flash Point:217 °C

Storage Temperature:?20°C

Refractive index:1.732

DMSO: 27 mg/mL

Biological Activity:Protein kinase inhibitor. Suppresses tumor-promoting effects of TPA and exhibits antiproliferative activity in human breast cancer cells (IC 50 values are 59.44 and 31.15 μ M at 24 and 72 hrs respectively). Activates both the intrinsic and extrinsic apoptotic pathways and displays anti-inflammatory, hypotensive, antispasmodic and antioxidant properties in vivo .

Usage:Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 uM) by inhibiting MAP kinase activity. Also inhibits the proliferation of malignant tumor cells by G2/M arrest and induces morphological diffe