What's Adefovir dipivoxil?

Adefovir dipivoxil's tradename is hepsera, a diester prodrug of adefovir. Adefovir is an acyclic nucleotide analog with activity against human hepatitis B virus (HBV).

The chemical name of adefovir dipivoxil is 9-[2-[[bis[(pivaloyloxy)methoxy]-phosphinyl]methoxy]ethyl]adenine. It has a molecular formula of C20H32N5O8P, a molecular weight of 501.48.


Adefovir dipivoxil (CAS.NO:142340 -99- 6) is a white to off-white crystalline powder with an aqueous solubility of 19 mg/mL at pH 2.0 and 0.4 mg/mL at pH 7.2. It has an octanol/aqueous phosphate buffer (pH 7) partition coefficient (log p) of 1.91.

Adefovir dipivoxil tablets are for oral administration. Each tablet contains 10 mg of adefovir dipivoxil and the following inactive ingredients: croscarmellose sodium, lactose monohydrate, magnesium stearate, pregelatinized starch, and talc.

This medication is used to treat a chronic viral infection of the liver (hepatitis B) in people 12 years of age and older. It works by slowing the growth of the virus. It is not a cure for hepatitis B and does not prevent the passing of hepatitis B to others. This medication is a nucleotide analog.


Name:Adefovir dipivoxil

EINECS:200-001-8

Molecular Formula:C20H32N5O8P

CAS Registry Number:142340-99-6

Molecular Weight:501.48

Density:1.35 g/cm3

Boiling Point:641 °C at 760 mmHg

Melting Point:98-102℃

Flash Point:641 °C at 760 mmHg

Storage Temperature:20°C

Refractive index:1.569

Merck  14,151

Hazard Codes  Xn

Risk Statements  20/21/22

Safety Statements  36/37