Gabapentin hydrochloride

Gabapentin hydrochloride is a White Crystalline Solid. It  is used as conventional anti-epileptic drugs, for who can not be satisfied with control or can not tolerate the limitations of seizures in patients with epilepsy, as well as additional treatment with the limitations, subsequently the body-oriented attack in patients with epilepsy.


1. Uses

Gabapentin hydrochloride(CAS.NO:60142-96-3) is used primarily to treat seizures, neuropathic pain, including concussions, and hot flashes.

2. Biological Activity

Anticonvulsant with several possible mechanisms of action. Increases GABA in the brain and binds to a novel site associated with voltage-sensitive Ca 2  channels. Prevents neuronal death and is antinociceptive and anxiolytic.

3. Mechanism of action

Gabapentin hydrochloride interacts with voltage-sensitive calcium channels in cortical neurons. Gabapentin hydrochloride increases the synaptic concentration of GABA, enhances GABA responses at non-synaptic sites in neuronal tissues, and reduces the release of mono-amine neurotransmitters. One of the mechanisms implicated in this effect of Gabapentin hydrochloride is the reduction of the axon excitability measured as an amplitude change of the presynaptic fibre volley (FV) in the CA1 area of the hippocampus. This is mediated through its binding to presynaptic NMDA receptors. Other studies have shown that the antihyperalgesic and antiallodynic effects of Gabapentin hydrochloride are mediated by the descending noradrenergic system, resulting in the activation of spinal alpha2-adrenergic receptors. Gabapentin hydrochloride has also been shown to bind and activate the adenosine A1 receptor.

3.Side effect

Get emergency medical help if you have any of these signs of an allergic reaction to Gabapentin hydrochloride: hives; fever; swollen glands; painful sores in or around your eyes or mouth; difficulty breathing; swelling of your face, lips, tongue, or throat.


Common Gabapentin hydrochloride side effects may include:

dizziness, drowsiness;

dry mouth, blurred vision;

headache;

diarrhea; or

swelling in your hands or feet.