2013年10月10日星期四

1A,25-dihydroxycholecalciferol application

1A,25-dihydroxycholecalciferol is a form of vitamin D that is used to treat and prevent low levels of calcium in the blood of patients whose kidneys or parathyroid glands (glands in the neck that release natural substances to control the amount of calcium in the blood) are not working normally. It is also called Calcitriol.Low blood levels of calcium may cause bone disease. 1A,25-dihydroxycholecalciferol is in a class of medications called vitamins. It works by helping the body to use more of the calcium found in foods or supplements.

1A,25-dihydroxycholecalciferol

1.Uses

Therapeutic doses of specific vitamin D analogs are used in the treatment of chronic hypocalcemia, hypophosphatemia, rickets, and osteodystrophy associated with various medical conditions including chronic renal failure, familial hypophosphatemia, and hypoparathyroidism (postsurgical or idiopathic, or pseudohypoparathyroidism).

1A,25-dihydroxycholecalciferol is prescribed for:
*Treatment of hypocalcaemia – hypoparathyroidism, osteomalacia (adults), rickets (infants, children), renal osteodystrophy, chronic renal dialysis
*Treatment of osteoporosis
*Prevention of corticosteroid-induced osteoporosis

1A,25-dihydroxycholecalciferol is also sometimes used topically in the treatment of psoriasis, however the evidence to support its efficacy is not well established.The vitamin D analogue calcipotriol is more commonly used for psoriasis. Research on the noncalcemic actions of 1A,25-dihydroxycholecalciferol and other VDR-ligand analogs and their possible therapeutic applications has been reviewed.

1A,25-dihydroxycholecalciferol is also administered orally for the treatment of psoriasis and psoriatic arthritis.


2.Side Effect

The main adverse drug reaction associated with calcitriol therapy is hypercalcaemia – early symptoms include: nausea, vomiting, constipation, anorexia, apathy, headache, thirst, sweating, and/or polyuria. Compared to other vitamin D compounds in clinical use (cholecalciferol, ergocalciferol), 1A,25-dihydroxycholecalciferol has a higher risk of inducing hypercalcaemia. However, such episodes may be shorter and easier to treat due to its relatively short half-life.

3.Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Protect this medication from light. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

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