Adefovir dipivoxil Medicine

Adefovir dipivoxil (Hepsera) is a nucleotide analog of adenosine monophosphate, which can inhibit reverse transcriptase and DNA polymerase activity . Adefovir has been evaluated as primary monotherapy for patients with chronic hepatitis B and in patients who developed resistance to lamivudine. It was approved by the FDA based upon the results of two phase 3 clinical trials in patients with HBeAg positive and HBeAg negative chronic hepatitis B and a compassionate use protocol for patients with decompensated cirrhosis or recurrent hepatitis B post-transplantation and lamivudine resistance. Several other studies evaluating adefovir in other populations have also been performed．

This medication is used to treat a chronic viral infection of the liver (hepatitis B) in people 12 years of age and older. It works by slowing the growth of the virus. It is not a cure for hepatitis B and does not prevent the passing of hepatitis B to others.This medication is a nucleotide analog.

SIDE EFFECTS: Weakness, headache, fever, increased cough, nausea, vomiting, diarrhea, or gas may occur. If any of these effects persist or worsen, notify your doctor promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if this very unlikely but serious side effect occurs: change in the amount of urine.For additional side effects see Warning section.An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor.

PRECAUTIONS: Before taking adefovir　dipivoxil, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: HIV infection, kidney problems, liver transplant, being very overweight (obese).This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

STORAGE: Store in the original container at room temperature (77 degrees F or 25 degrees C) away from light and moisture. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Keep away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed.