What’s the 5-Bromonicotinic acid？

　　5-Bromonicotinic acid, C6H4BrNO2, it’s synonyms is 5-Bromo-3-pyridinecarboxylic acid.it is a kind of Pharmaceutical Intermediates which colour is light yellow. Next is a brief introduces about its Physical and chemical properties.

5-Bromonicotinic acid,20826-04-4

    1.Physical properties of 5-Bromonicotinic acid
　　Classification:Pharmaceutical Intermediates
　　EINECS:244-065-5
    CAS Registry Number：20826-04-4
　　Molecular Formula:C6H4BrNO2
　　Melting Point:178-184℃
　　Boiling Point:328.5 °C at 760 mmHg
　　Stability:Stable at room temperature in closed containers under normal storage and handling conditions.
　　Flash Point:152.5 °C
　　Appearance:Light yellow
　　Cryst Hazard Class:IRRITANT
    2.Chemical Properties, and Production of 5-Bromonicotinic acid
　　Category: toxic substances
　　Toxicity rating: high toxicity
　　Acute toxicity: celiac - Mouse LD50: 462 mg / kg
　　Health Hazard: Combustible; Thermal decomposition produces toxic fumes of nitrogen oxides and bromides; react with oxidants
　　Storage features: Treasury ventilated low-temperature drying; with oxidants, food additives separately
　　Extinguishing Media: Carbon dioxide, foam, sand, water mist
    3.Usage of 5-Bromonicotinic acid
Niacin (also called Nicotinic Acid) and Niacinamide (also called Nicotinamide), two compounds of water-soluble vitamin B complex, are active in the metabolism of body. Chemically they are 3-Pyridinecarboxylic acid and 3-Pyridinecarboxamide respectively. Commercially, niacin is obtained from beta -picoline or from quinoline, which are both obtainable from coal tar. Niacinamide, more water soluble, is the amide form of niacin. When an amide molecule attaches itself to niacin, it becomes niacinamide. The B vitamins niacin and niacinamide are known as preventives of pellagra. Niacin is interchangeable in metabolism with its amide, niacinamide. Nicotinamide is hydrolyzed to the acid in the digestive tract of non-ruminants. After absorption in the mucosa, the amide is formed again. In the rumen of ruminants, nicotinamide is converted in a short time to nicotinic acid. Nicotinamide and nicotinic acid are therefore equivalent in action in the case of farm animals. These are key ingredients in animal feed and animal feed premixes as these contribute to numerous metabolic reactions  as hydrogen transferring coenzymes. Niacin acts to reduce plasma cholesterol, as a vasodilator and to treat pellagra.Niacin is used for the prophylaxis. Their derivatives are used for these effects. 5-Bromonicotinic acid is used as an intermediate for agro chemcials, feed additives, pharmaceuticals and animal food enrichments.