Basic information of Candesartan

　　Candesartan is an angiotensin receptor blocker (also called an angiotensin-II receptor antagonist or an AIIRA).It's CAS Registry Number is 139481-59-7. It is used to treat hypertension (high blood pressure) and heart failure (a condition where the pumping action of the heart is reduced). People with high blood pressure often do not feel unwell but, left untreated, high blood pressure can harm the heart and damage blood vessels.


Candesartan,139481-59-7


　　Candesartan works by blocking the effect of a chemical called angiotensin II which is made in your bloodstream. Angiotensin II causes your blood vessels to narrow, so by blocking this effect, candesartan allows your blood vessels to relax and widen. As this happens, the pressure of blood within your blood vessels is reduced. This also makes it easier for your heart to pump blood around your body.
　　1.How to take candesartan?　　*Before you start this treatment, read the manufacturer's printed information leaflet from inside the pack. The leaflet will give you more information about the brand of candesartan you have been given, and a full list of possible side-effects from taking it.
　　*Take candesartan exactly as your doctor has told you to. It is usually taken once each day. Your dose will be on the label of your pack.
　　*Take candesartan at a time of day you find easy to remember, and try to take your doses at the same time on each day. This will help you to avoid missing any doses. You can take candesartan tablets before or after meals.
　　*If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, skip the missed dose. Do not take two doses together to make up for a forgotten dose.
　　 2.Dosage　　 The recommended dose range of candesartan for adults is 4 to 32 mg once daily. The usual starting dose for hypertension is 16 mg daily, and the starting dose for treating heart failure is 4 mg once daily. Doses may be doubled at 2 week intervals as tolerated by patients. The maximum dose is 32 mg daily.
　　3.Can candesartan cause problems?
　　Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.
　　4.How to store candesartan?　　*Keep all medicines out of the reach and sight of children.
　　*Store in a cool, dry place, away from direct heat and light.Tablets should be stored at room temperature, between 15-30 C (59-86 F).
　　5.Side effects　　The most common side effects of candesartan includeheadache, dizziness, fatigue, abdominal discomfort, diarrhea, and upper respiratory infections. Patients may also experience hyperkalemia,impotence, reduced renal function, and allergic reactions. Rhabdomyolysis(inflammation and destruction of muscle) and angioedema (swelling of soft tissues including those of the throat and larynx) are rare but serious side effects of candesartan.