Neomycin sulfate

Neomycin is produced by Streptomyces fradiae. Polymyxin B Sulfate acts by binding to the 30S subunit of the bacterial ribosome leading to inhibition of protein synthesis and death in susceptible bacteria. Neomycin Sulfate is used for the prevention of bacterial contamination of cell cultures. This antibiotic is highly active against gram-negative bacteria. The recommended working concentration is 50 µg/ml. Life Technologies offers a variety of antibiotics and antimycotics for cell culture applications.


Name:Neomycin sulfate

EINECS:215-773-1

Molecular Formula:C23H46N6O13.3(H2SO4)

CAS Registry Number:1405-10-3

HS Code:29419000

Appearance:Tan powder.

Molecular Weight:908.87

Boiling Point:1046.1°C at 760 mmHg

Flash Point:586.5°C

Storage Temperature:2-8°C

Refractive index:56 ° (C=10, H2O)

Solubility:500 g/L (20 C)

Stability:Stable. Incompatible with strong oxidizing agents.

Usage:Antibacterial.

Indications: It is prescribed orally to treat hepatic coma and infections of the intestine and to prepare the gastrointestinal tract for surgery. It is prescribed topically to treat skin infections.

Contraindications: Renal dysfunction, intestinal obstruction, or known hypersensitivity to this drug or to any aminoglycoside medication prohibits its use. Neomycin is not administered parenterally.


Adverse effects: Among the more serious adverse effects are nausea, vomiting, diarrhea, malabsorption, or superinfection. Prolonged treatment in patients with impaired renal function may result in the toxicities of systemic aminoglycosides (e.g., ototoxicity, nephrotoxicity, neuromuscular toxicity). Hypersensitivity reactions may occur with topical administration of this drug.