Introduction to 1,2,4-1H-Triazole

1,2,4-1H-Triazole is one of a pair of isomeric chemical compounds with molecular formula C2H3N3, called triazoles, which have a five-membered ring of two carbon atoms and three nitrogen atoms. 1,2,4-1H-Triazole is a basic aromatic heterocycle. 1,2,4-1H-Triazole derivatives find use in a wide variety of applications, most notably as antifungals such as fluconazole and itraconazole.


1.Chemical properties

Name:1,2,4-1H-Triazole

EINECS:206-022-9

Molecular Formula:C2H3N3

CAS Registry Number:288-88-0

Synonyms:1H-1,2,4-1H-Triazole; 1,2,4-Triazole; 1H-1,2,4Triazole; 1,2,4-1H-1,2,4-1H-Triazole; Triazole

InChI:InChI=1/C2H3N3/c1-3-2-5-4-1/h1-2H,(H,3,4,5)

HS Code:29339990

Appearance:white crystalline powder and flakes

Molecular Weight:69.07

Density:1.274g/cm3

Boiling Point:260℃

Melting Point:119-122℃

Flash Point:140℃

Storage Temperature:Store at 0-5°C

Refractive index:1.534

Solubility:Water solubility: 1250 g/L at 20 °C

Stability:Stable under normal temperatures and pressures.

Usage:Used to produce antifungals.

2. First Aid Measures

Ingestion:Get medical aid. Wash mouth out with water.

Inhalation:Remove from exposure to fresh air immediately.

Skin:Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes:Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.

3. Handling and Storage

Storage:Store in a cool, dry place. Store in a tightly closed container.

Handling:Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.

4.Hazards Identification
Ingestion:Harmful if swallowed. May cause irritation of the digestive tract.

Inhalation:May cause respiratory tract irritation. May be harmful if inhaled.

Skin:May be harmful if absorbed through the skin.

Eyes:Causes eye irritation.

EC Risk Phrase:R 22 36 63

EC Safety Phrase:S 36/37

5. Exposure Controls/Personal Protection

1)Personal Protection:

Skin: Wear appropriate protective gloves to prevent skin exposure.

Clothing: Wear appropriate protective clothing to prevent skin exposure.

2)Respirators:


Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.