Properties of Proline

Proline (abbreviated as Pro or P) is an α-amino acid, one of the twenty DNA-encoded amino acids. Its codons are CCU, CCC, CCA, and CCG. It is not an essential amino acid, which means that the human body can synthesize it. It is unique among the 20 protein-forming amino acids in that the amine nitrogen is bound to not one but two alkyl groups, thus making it a secondary amine. The more common L form has S stereochemistry.

Proline and its derivatives are often used as asymmetric catalysts in organic reactions. The CBS reduction and proline catalysed aldol condensation are prominent examples. L-Proline is an osmoprotectant and therefore is used in many pharmaceutical, biotechnological applications.

D-Proline (CAS NO.344-25-2) is used as synthesizing the drugs. D-Proline , with CAS number of 344-25-2, It is a white to off-white powder.

1.Properties

Name:Proline

EINECS:206-452-7

Molecular Formula:C5H9NO2

CAS Registry Number:344-25-2

Synonyms:D-Prolin; (R)-pyrrolidine-2-carboxylic acid; D-Proline; (2R)-pyrrolidine-2-carboxylic acid; H-D-Pro-OH; D-(+)-Proline; D-Pyrrolidine-2-carboxylic acid; D-(+)-proline; D-Pyrrolidine-2-carboxylic acid; D-Proline (Food Grade);

InChI:InChI=1/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1

Appearance:White to off-white powder

Molecular Weight:115.13

Density:1.186g/cm3

Boiling Point:252.2 °C at 760 mmHg

Melting Point:223℃

Flash Point:106.3 °C

Alpha:84.75 o (C=4, H2O)

Storage Temperature:Store at RT.

Refractive index:85 ° (C=4, H2O)

Solubility:Soluble

Stability:Stable under normal temperatures and pressures.

Usage: Used in the synthesis of (R)-(+)-N-Boc-Pipecolic Acid, (S)-(-)-Coniine, (S)-(+)-Pelletierine, (+)-.beta.-Conhydrine, and (S)-(-)-Ropivacaine and formal synthesis of (-)-Lasubine II and (+)-Cermizine C.

Usage: Labelled D-Proline

2. Safety Information


Hazard Codes of D-Proline (CAS NO.344-25-2): Xi,Xn

Risk Statements: 22-36/37/38

R22: Harmful if swallowed.

R36/37/38: Irritating to eyes, respiratory system and skin.

Safety Statements: 22-24/25-36/37/39-26

S22: Do not breathe dust.

S24/25: Avoid contact with skin and eyes.

S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.

S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

WGK Germany: 3

F: 3-10

Hazard Note: Irritant