Cisplatin Chemical Information

The Cisplatin, with the CAS registry number 15663-27-1,is also known as cis-Diaminedichloroplatinum(II). It belongs to the product categories of ammine metal halide;Anti Cancer Reagents;chemical reaction,pharm,electronic,materials. Its EINECS number is 239-733-8. This chemical's molecular formula is Cl2H6N2Pt and molecular weight is 300.05. What's more,Its systematic name is Cisplatin.It is a Crystalline which is an inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.



Name:Cisplatin

EINECS:239-733-8

Molecular Formula:Cl2H6N2Pt

CAS Registry Number:15663-27-1

Appearance:Orange-yellow to deep yellow solid or powder

Molecular Weight:300.05

Density:3.7

Melting Point:270℃

Storage Temperature:Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked. Keep containers tightly closed.

Solubility:<0.1 g/100 mL at 19 oC in water

Biological Activity:Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF- α -induced apoptosis.

Stability:Stable. Incompatible with oxidizing agents, aluminium, antioxidants

Usage:Used as an antineoplastic

Chemical Properties: Crystalline

Usage: Used as an antineoplastic

General Description: An anticancer drug. Orange-yellow to deep yellow solid or powder


Air & Water Reactions: Insoluble in water.

Reactivity Profile: Cisplatin is incompatible with oxidizing agents. Cisplatin is also incompatible with aluminum. Cisplatin may react with sodium bisulfite and other antioxidants.

Fire Hazard: Flash point data for Cisplatin are not available; however, Cisplatin is probably combustible.

Safety Information of Cisplatin:


The Cisplatin is Irritating to eyes, respiratory system and skin and it may cause sensitization by inhalation and skin contact. so it should avoid exposure - obtain special instructions before use. It is risk of serious damage to the eyes.  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. When you use it ,wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)