Medicine:Metformin Hydrochloride

Metformin Hydrochloride Tablets 500mg belong to a group of medicines called biguanide oral anti−hyperglycaemic agents. It works by lowering your blood−sugar level.

Metformin Hydrochloride(CAS.NO:1115-70-4) is used to treat non−insulin dependent diabetes when a change of diet has failed to reduce blood sugar levels, particularly if overweight.It may be used alone as initial therapy or along with another group of medicines called sulphonylureas, which stimulate the pancreas to produce more insulin. Sometimes Metformin Hydrochloride is also used to treat patients suffering from insulin dependent diabetes, who are over weight (obese) and whose symptoms are poorly controlled.

If your blood sugar levels are not controlled, it can lead to serious problems such as kidney damage, amputations and blindness. Metformin Hydrochloride is thought to work by decreasing the amount of sugar absorbed from food through the stomach, by helping the body respond better to the insulin it makes naturally and by decreasing the amount of sugar produced by the liver and kidneys.


1. Introduction of Metformin hydrochloride

Metformin hydrochloride is one kind of crystalline solid or white powder. The IUPAC Name of this chemical is 3-(Diaminomethylidene)-1,1-dimethylguanidine hydrochloride. Besides, Metformin hydrochloride belongs to Intermediates & Fine Chemicals; Pharmaceuticals; API's; Miscellaneous Compounds. In addition, Metformin hydrochloride Classification Code is Antidiabetic; Drug / Therapeutic Agent; Skin / Eye Irritant. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether and chloroform.

2. Uses of Metformin hydrochloride

Metformin hydrochloride is an oral hypoglycemic agent. It can lower plasma glucose levels and improves insulin sensitivity. Metformin hydrochloride Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines.

3. Production of Metformin hydrochloride

Metformin hydrochloride is derived by Dimethylamine salt reacting with Dicyandiamide

4. Mechanism of Action


Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Its pharmacologic mechanisms of action are different from other classes of oral antihyperglycemic agents. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Unlike sulfonylureas, metformin does not produce hypoglycemia in either patients with type 2 diabetes or normal subjects (except in special circumstances, see PRECAUTIONS) and does not cause hyperinsulinemia. With metformin therapy, insulin secretion remains unchanged while fasting insulin levels and day-long plasma insulin response may actually decrease.