Intro to Flumethasone

　　Flumetasone (usually as the pivalic acid ester flumetasone pivalate, trade name Locacorten or Locorten) is acorti costeroid for topical use. It is available in combination with clioquinol, under the trade name Locacorten-Vioform (in some countries Locorten-Vioform), for the treatment of otitis externa and otomycosis.

Flumethasone,2135-17-3

　　1.Mechanism of action
　　Flumethasone is a glucocorticoid receptor agonist. This complex binds to the nucleus causing a variety of genetic activation and repressions. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Flumethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin.
　　2.flumethasone with clioquinol ear drops
　　USES: This medication is used to treat external ear infections or, when used in combination with oral antibiotics, to treat middle ear infections
　　HOW TO USE: This drug is for use in the ear only. Learn proper ear cleaning and device usage techniques. Consult your doctor and pharmacist. Hold container in the hand for a few minutes if it has been refrigerated in order to warm it. To avoid contamination of the device do not touch the dropper tip or let it touch your ear or any other surface. For accuracy, have another person insert the drops for you if possible. To apply ear drops, wash hands first, then completely clean the ear canal. The usual dose is 2 to 3 drops twice daily or as directed by your doctor. Lie on your side or tilt the affected ear upward and place the prescribed number of drops into the ear. To help the drops roll into the ear (for adults) hold the earlobe up and back or (for children) hold the earlobe down and back. Keep the ear tilted for about two minutes so the medicine will be well absorbed or insert a soft cotton plug if so directed. Do not rinse the dropper. Replace cap after use. For best results, this medication must be used routinely as directed. Continue using it for the full time prescribed. Stopping this medication too soon may result in reinfection.